Impaired aerobic work capacity in insulin dependent diabetics with increased urinary albumin excretion
نویسندگان
چکیده
منابع مشابه
Elevated urinary albumin excretion is associated with impaired arterial dilatory capacity in clinically healthy subjects.
BACKGROUND Elevated urinary albumin excretion (UAE) predicts atherosclerotic cardiovascular disease. It is hypothesized that elevated UAE is associated with a generalized vascular dysfunction. This study tested this hypothesis for conduit arteries. METHODS AND RESULTS Clinically healthy subjects were selected: 19 with UAE >90th percentile in the background population (6.6 microgram/min<UAE<15...
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We measured concentrations of transferrin (TRF, in micrograms), and creatinine (Cr, in millimoles) in samples of untimed urine from 53 healthy subjects and 157 non-insulin-dependent diabetic (NIDD) subjects. The urinary TRF/Cr ratio was significantly higher in the NIDD group (P less than 0.001). If NIDD subjects are grouped according to their Alb/Cr ratio into normal albuminuria (Group A, Alb/C...
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Despite the first-line use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), there is still a large need to improve the prevention and progression of diabetic nephropathy and its associated cardiovascular events. Endothelin antagonists have shown anti-inflammatory, antifibrotic, and antiproteinuric effects in experimental studies. This study was a ran...
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As angiotensin-converting enzyme inhibition is accompanied by a marked decrease in glomerular protein loss, the hypothesis was tested that an increase of the glomerular transcapillary hydraulic pressure difference by exogenous angiotensin II would increase microalbuminuria in patients with insulin (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM). Acute effects of increasing doses of a...
متن کاملUrinary albumin excretion rate and its determinants after 6 years in non-insulin-dependent diabetic patients.
BACKGROUND The present study was undertaken to clarify the progression of urinary albumin excretion rate (UAER) in non-insulin-dependent diabetic (NIDD) patients 6 years after diagnosis, and to elucidate the risk factors of nephropathy. METHODS This is a population-based controlled (baseline) cohort study. The prospective evaluation utilized the diabetic patients as internal controls. The set...
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ژورنال
عنوان ژورنال: BMJ
سال: 1988
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.296.6633.1352